This is where CarnoSyn^® comes in—offering a holistic solution that not only addresses cognitive well-being but also helps maintain muscle health and physical function. With its carnosine-boosting effects, CarnoSyn^® emerges as a unique supplement to help counterbalance muscle mass loss and performance challenges faced by individuals using GLP-1 receptor agonists.

Challenges with GLP-1 Therapies: Muscle Loss and Nutritional Deficiencies

GLP-1 receptor agonists work by mimicking natural hormones that regulate appetite and insulin response. While these medications are highly effective for weight loss and blood sugar management, they may also pose a risk of reducing muscle mass, particularly if weight loss happens rapidly. Some users report decreased energy levels, endurance, and physical strength, which can impair overall well-being.

Moreover, people on these therapies may develop nutritional deficiencies, as reduced appetite leads to lower intake of key nutrients required for muscle health and cognitive function. Several brands and healthcare providers are now focusing on this issue, recommending that individuals incorporate muscle-supportive supplements into their routines to help mitigate the side effects of GLP-1 therapy.

How CarnoSyn^® Helps Support Muscle and Cognitive Health
CarnoSyn^® addresses the muscle and cognitive challenges associated with GLP-1 receptor agonists through a science-backed, multi-functional approach:

1. Carnosine Boost for Muscle Endurance and Fatigue Reduction
   Carnosine, a dipeptide found in muscles, plays a critical role in reducing muscle fatigue and enhancing endurance. CarnoSyn^® boosts carnosine levels, which helps maintain muscle function and helps reduce the risk of performance decline during GLP-1 therapy. This is especially relevant for individuals engaging in exercise to retain muscle mass and prevent muscle degradation.
2. Support for Cognitive Performance and Mental Clarity
   In addition to muscle health, CarnoSyn^® also helps modulate critical brain biomarkers such as BDNF (brain-derived neurotrophic factor) and GFAP (glial fibrillary acidic protein). These biomarkers are essential for brain function, memory, and mood regulation. GLP-1 users, who sometimes experience fatigue or cognitive fog, may benefit from the CarnoSyn^® formula’s ability to support cognitive resilience and mental clarity.
3. A Holistic Approach: Cognitive and Physical Health Synergy
   Unlike many supplements that focus on only one aspect of well-being, CarnoSyn^® delivers a comprehensive solution by supporting both physical and cognitive performance. For people on GLP-1 therapies, maintaining both brain function and muscle strength may be essential for achieving sustainable, long-term health.

Why CarnoSyn^® is a Valuable Addition for GLP-1 Users

1. Muscle Preservation – CarnoSyn^® helps counteract muscle mass loss with its carnosine-boosting effects, helping users to stay active and maintain physical function.
2. Cognitive Support – By helping to modulate biomarkers like BDNF and GFAP, CarnoSyn^® supports mental clarity and cognitive resilience.
3. Fatigue Reduction – CarnoSyn^® helps reduce muscle fatigue, enabling users to maintain energy levels for daily activities and workouts.

Conclusion: A Comprehensive Addition for GLP-1 Users
As GLP-1 receptor agonists become more widely used, it is essential to address the possible side effects that may accompany their benefits. CarnoSyn^® offers a comprehensive solution, helping individuals maintain muscle strength, cognitive function, and energy levels—three critical elements for long-term well-being.

The post Science Spotlight – Supporting Muscle Health and Cognitive Performance for Individuals on GLP-1 Therapies appeared first on CarnoSyn.

Study Highlights:

• TriBsyn is an encapsulated low-dose β-alanine complex.
• TriBsyn increased plasma β-alanine 4.5-fold compared to conventional β-alanine.
• TriBsyn achieved high plasma concentrations without the sensation of paresthesia.

TriBsyn is a carnosine booster derived from CarnoSyn^® beta-alanine and formulated using proprietary Hydro Oleo technology. This patent-pending formulation provides higher bioavailability and higher potency, enabling efficacious dosages at lower volumes while effectively eliminating paresthesia. The advanced formulation enables absorption through multiple pathways, including direct cellular uptake and traditional gastrointestinal routes, allowing for superior delivery at both the cellular and systemic levels. Adequate availability of beta-alanine is critical for maintaining muscle and promoting cognitive well-being. Efficacious doses of beta-alanine are often associated with harmless but generally uncomfortable symptoms of paresthesia, discouraging adherence to supplementation.

This study aimed to evaluate the bioavailability, pharmacokinetics, and tolerability of a 400 mg Hydro Oleo encapsulated beta-alanine complex (TriBsyn) specifically designed to reduce paresthesia. A randomized, double-blind, single-dose, three-treatment, three-way crossover oral bioavailability study was conducted in healthy older adults under fasting conditions. The study compared TriBsyn with low (400 mg) and high (1200 mg) doses of conventional beta-alanine. TriBsyn (400 mg) achieved a nearly 4.5-fold and 1.3-fold increase in circulating beta-alanine plasma concentrations compared to 400 mg and 1200 mg of conventional beta-alanine, respectively.

Using metrics such as the Visual Analogue Score (VAS) and Qualitative Light Symptoms Inventory (QLSI), sensory side effects were assessed. No paresthesia or adverse effects were reported in the TriBsyn group, while the conventional beta-alanine groups exhibited increasing paresthesia with dose. TriBsyn (400 mg beta-alanine) recorded a VAS score of 0.62 (indicating almost absent symptoms), whereas conventional β-alanine (400 mg) and conventional β-alanine (1200 mg) scored 2.02 and 4.01 respectively. These results highlight the reduced sensory discomfort in the TriBsyn group, despite its higher bioavailability.

“The TriBsyn clinical trial results clearly showed the elimination of paresthesia and an increased pharmacokinetic efficiency, confirming enhanced delivery and exceptional bioavailability,” said Ken Wolf, President and COO of Natural Alternatives International. “With its advanced Hydro Oleo technology and carnosine-boosting effects, TriBsyn provides scientifically proven claims to improve muscle vitality, muscle working capacity, and cognitive performance. It truly sets a new standard in beta-alanine supplementation and helps fill the gap for healthy aging and wellness solutions—especially for the active aging population, GLP-1 users, and those with plant-based diets.”

About CarnoSyn^® Brands:
CarnoSyn^® Brands features three clinically studied, patented and patent pending ingredients available exclusively from Natural Alternatives International, Inc.: CarnoSyn^® instant release beta-alanine powder, SR CarnoSyn^® sustained release beta-alanine tablets, and TriBsyn powder. In 2019, CarnoSyn^® beta-alanine successfully obtained NDI status from the FDA and received Self-Affirmed GRAS (Generally Recognized as Safe) status. SR CarnoSyn^®, an advanced delivery form of CarnoSyn^®, received GRAS affirmation in 2017. The new “paresthesia-free” TriBsyn powder allows NAI to broaden their product offerings within the dietary supplement category, medical food and other fortified food products. To learn more about CarnoSyn^® and SR CarnoSyn^® in sports nutrition and wellness, visit www.carnosyn.com and www.srcarnosyn.com. For more information about our latest innovation, TriBsyn, visit www.tribsyn.com.

About NAI:
NAI, headquartered in Carlsbad, California, is a leading formulator, manufacturer and marketer of nutritional supplements and provides strategic partnering services to its customers. NAI’s comprehensive partnership approach offers a wide range of innovative nutritional products and services to clients including scientific research, proprietary ingredients, customer-specific nutritional product formulation, product testing and evaluation, marketing management and support, packaging and delivery system design, regulatory review, and international product registration assistance. For more information about NAI, please visit www.nai-online.com.

Contact:
Renee Michaelson
Director of Global Marketing
NAI/CarnoSyn^® Brands
info@nai-online.com 

The post Natural Alternatives International and CarnoSyn® Brands Publish Clinical Research Demonstrating TriBsyn™ Delivering Exceptional Bioavailability, Increased Efficiency and Paresthesia Elimination appeared first on CarnoSyn.

Under the terms of the agreement, B&D will distribute NAI’s newly introduced carnosine booster, TriBsyn, to the U.S.-based nutritional dietary supplement, functional food, and beverage market segments. Carnosine, which is naturally produced in the body through the synthesizing of beta-alanine and histidine, is a powerful antioxidant that has been shown to provide health benefits for muscle, brain, heart, bone, and overall systemic health. NAI’s new TriBsyn product is a patent-pending ingredient that utilizes proprietary technology to increase beta-alanine bioavailability and absorption, while effectively eliminating the common paresthesia sensation associated with efficacious dosages of beta-alanine. TriBsyn provides the opportunity to reach untapped consumers from older adults to vegetarians, vegans, and others looking to boost their carnosine levels.

“This strategic partnership between NAI and B&D is a testament to our longstanding business relationship,” said Mark LeDoux, CEO and Chairman of the Board at NAI. “B&D’s reputation and commitment to their customers is unwavering. This distribution agreement will help drive the awareness and growth of the TriBsyn innovation launched in August 2024. We are excited to broaden our distribution efforts with B&D and to share our groundbreaking new ingredient with the industry.”

B&D is a leading distributor specializing in the dietary supplement, functional food and beverage, personal care, pet health, and craft brewery industries. TriBsyn represents the latest innovative ingredient added to B&D’s specialty ingredient portfolio for distribution. Their well-stocked warehouse complements just-in-time inventory needs, and a deep understanding of the industry makes B&D a first-class partner.

“B&D is honored to be NAI’s partner to promote TriBsyn,” stated Bill Van Dyke, B&D President. “TriBsyn fits B&Ds’ portfolio and model extremely well by being a clinically supported and unique dietary ingredient. We believe TriBsyn will be an excellent ingredient for anti-aging, cognitive function, and support of physical activity.”

About B&D Nutritional Ingredients, Inc.
Founded in 1993 and based in Carlsbad, California, B&D Nutritional Ingredients, Inc. is a national leader in the sales, distribution, and marketing of high-quality dietary ingredients and flavors to the dietary supplement, functional food and beverage, personal care, pet health, and craft brewery industries. B&D has a portfolio of premium ingredients from leading manufacturers supporting a wide array of health benefits that today’s consumers are looking for. B&D is active in several industry organizations representing the dietary supplement, personal care, and pet health industries. Memberships include, Natural Products Association, Consumer Healthcare Products Association, Association of American Feed Control Officials, National Animal Supplement Council. For more information, visit www.bdnutritional.com.

About CarnoSyn^® Brands:
CarnoSyn^® Brands feature three clinically studied, patented ingredients available exclusively from Natural Alternatives International, Inc.: CarnoSyn^® instant release beta-alanine powder, SR CarnoSyn^® sustained release beta-alanine tablets, and TriBsyn powder. In 2019, CarnoSyn^® beta-alanine successfully obtained NDI status from the FDA and received Self-Affirmed GRAS (Generally Recognized as Safe) status. SR CarnoSyn^®, an advanced delivery form of CarnoSyn^®, received GRAS affirmation in 2017. The new “paresthesia-free” TriBsyn powder allows NAI to broaden their product offerings within the dietary supplement category, including medical and other fortified food products. To learn more about SR CarnoSyn^® in active nutrition and wellness, visit www.srcarnosyn.com. For more information about the latest innovation, TriBsyn, visit www.tribsyn.com.

About NAI:
NAI, headquartered in Carlsbad, California, is a leading formulator, manufacturer and marketer of nutritional supplements and provides strategic partnering services to its customers. NAI’s comprehensive partnership approach offers a wide range of innovative nutritional products and services to clients including scientific research, proprietary ingredients, customer-specific nutritional product formulation, product testing and evaluation, marketing management and support, packaging and delivery system design, regulatory review, and international product registration assistance. For more information about NAI, please visit www.nai-online.com.

Contact:
Renee Michaelson
Director of Global Marketing
NAI/CarnoSyn^® Brands
(760) 736-7700
info@nai-online.com 

The post CarnoSyn® Brands Announces New U.S. Distribution Agreement With B&D Nutritional Ingredients appeared first on CarnoSyn.

The NAI and CarnoSyn^® Brands team will be available at stand #16 to discuss the latest clinical evidence of TriBsyn, a patent-pending ingredient that utilizes proprietary technology to increase beta-alanine bioavailability and absorption, while effectively eliminating the common paresthesia sensation associated with efficacious dosages of beta-alanine. TriBsyn provides new opportunity to reach untapped consumers from older adults to vegans and anyone focused on wellness. Congress attendees are invited to visit the stand to learn more about this new product innovation.

Aaron Starr, Vice President, CarnoSyn^® Brands stated, “We are excited to exhibit TriBsyn at this year’s ESPEN Congress on Clinical Nutrition and Metabolism and to share details behind the clinically proven ingredient. There is an evolving need and growing demand for healthy aging and wellness solutions, and this proprietary carnosine booster is a game changer for dietary supplement categories, as well as for fortified and medical foods, seeking benefit focus on muscle vitality, cognitive performance, and anti-aging support.”

Following ESPEN, the team will attend the 20^th European Geriatric Medicine Society (EuGMS) Congress in Valencia, Spain on September 18-20.

Find out more about TriBsyn by visiting ESPEN stand #16 or www.tribsyn.com.

About CarnoSyn^® Brands:
CarnoSyn^® Brands feature three clinically studied, patented ingredients available exclusively from Natural Alternatives International, Inc.: CarnoSyn^® instant release beta-alanine powder, SR CarnoSyn^® sustained release beta-alanine tablets, and TriBsyn powder. In 2019, CarnoSyn^® beta-alanine successfully obtained NDI status from the FDA and received Self-Affirmed GRAS (Generally Recognized as Safe) status. SR CarnoSyn^®, an advanced delivery form of CarnoSyn^®, received GRAS affirmation in 2017. The new “paresthesia-free” TriBsyn powder allows NAI to broaden their product offerings within the dietary supplement category, including medical and other fortified food products. To learn more about SR CarnoSyn^® in active nutrition and wellness, visit www.srcarnosyn.com. For more information about the latest innovation, TriBsyn, visit www.tribsyn.com.

About NAI:
NAI, headquartered in Carlsbad, California, is a leading formulator, manufacturer and marketer of nutritional supplements and provides strategic partnering services to its customers. NAI’s comprehensive partnership approach offers a wide range of innovative nutritional products and services to clients including scientific research, proprietary ingredients, customer-specific nutritional product formulation, product testing and evaluation, marketing management and support, packaging and delivery system design, regulatory review, and international product registration assistance. For more information about NAI, please visit www.nai-online.com.

Contact:
Renee Michaelson
Director of Global Marketing
NAI/CarnoSyn^® Brands
(760) 736-7700
info@nai-online.com 

The post CarnoSyn® Brands Showcasing TriBsyn™ at the 46th ESPEN Congress On Clinical Nutrition & Metabolism appeared first on CarnoSyn.

The proprietary TriBsyn formulation successfully removes the common paresthesia sensation associated with efficacious dosages of beta-alanine, creating a brand-new opportunity to reach untapped consumers from older adults to vegetarians and vegans.

Increased carnosine levels have been scientifically proven to provide a significant range of support for general wellness, including:

• Bolstering cognitive performance and improving mental fatigue
• Increasing both muscle function and quality in older adults
• Slowing the process of age-related health and mental decline

In clinical trials, results showed the elimination of paresthesia and an increased pharmacokinetic efficiency, confirming TriBsyn’s enhanced delivery and exceptional bioavailability—improving the absorption of beta-alanine by more than four times compared to conventional beta-alanine. The increased efficiency allows for product formulations with significantly less beta-alanine, thereby improving formulation flexibility for various delivery systems.

“After extensive research and trials, we are proud to announce TriBsyn, which contains CarnoSyn^®, the only beta-alanine approved by the FDA under NDI status,” said Aaron Starr, Vice President, CarnoSyn^® Brands. “With the innovation of a paresthesia-free beta-alanine, TriBsyn sets a new standard in beta-alanine supplementation, ensuring that users can experience the full range of health benefits without the paresthesia or ‘tingling’ often experienced as a side effect. We eagerly anticipate the commercial launch of TriBsyn at our first industry event in September, at the 46th ESPEN Congress on Clinical Nutrition & Metabolism in Milan, Italy.”

Ken Wolf, President of NAI shared, “TriBsyn’s launch will bolster our presence in a plethora of dietary supplement categories as well as fortified and medical foods. There is an evolving need and growing demand for healthy aging and wellness solutions—particularly for the aging population and those with plant-based diets. We look forward to sharing this revolutionary new product with our existing customers as well as creating a new customer following.”

To learn more about TriBsyn visit www.tribsyn.com.

About CarnoSyn^® Brands:
CarnoSyn^® Brands feature three clinically studied, patented ingredients available exclusively from Natural Alternatives International, Inc.: CarnoSyn^® instant release beta-alanine powder, SR CarnoSyn^® sustained release beta-alanine tablets, and TriBsyn powder. In 2019, CarnoSyn^® beta-alanine successfully obtained NDI status from the FDA and received Self-Affirmed GRAS (Generally Recognized as Safe) status. SR CarnoSyn^®, an advanced delivery form of CarnoSyn^®, received GRAS affirmation in 2017. The new “paresthesia-free” TriBsyn powder allows NAI to broaden their product offerings within the dietary supplement category, including medical and other fortified food products. To learn more about SR CarnoSyn^® in active nutrition and wellness, visit www.srcarnosyn.com. For more information about the latest innovation, TriBsyn, visit www.tribsyn.com.

About NAI:
NAI, headquartered in Carlsbad, California, is a leading formulator, manufacturer and marketer of nutritional supplements and provides strategic partnering services to its customers. NAI’s comprehensive partnership approach offers a wide range of innovative nutritional products and services to clients including scientific research, proprietary ingredients, customer-specific nutritional product formulation, product testing and evaluation, marketing management and support, packaging and delivery system design, regulatory review, and international product registration assistance. For more information about NAI, please visit www.nai-online.com.

Contact:
Renee Michaelson
Director of Global Marketing
NAI/CarnoSyn^® Brands
(760) 736-7700
info@nai-online.com 

The post CarnoSyn® Brands Unveils TriBsyn™ – “The World’s First Paresthesia-Free Beta-Alanine Powder” appeared first on CarnoSyn.

While women lead men in dietary supplement purchases, the industry is lacking in female-specific research to support women’s health. The need for this research is not only in regard to female athletes but also to women living active lifestyles. For example, more research is needed that considers the different life stages of women such as perimenopause, menopause, and postmenopause, in both athletes and non-athletes alike. Brands can then use this data to generate new ideas, invest in innovation efforts, and develop new products to support the vast population of women seeking better ways to improve their health and performance through various life stages.

In female study populations ranging from young to old and various levels of physical fitness, the amino acid beta-alanine showed potential benefits.

Insider Takes

• Naturally occurring amino acid beta-alanine supports the synthesis of muscle carnosine in the body.
• Beta-alanine has shown noteworthy effects specific to women of varying ages and athletic abilities.
• Female study populations included aging elite cyclists, young women, masters athletes and actives.

In the U.S., roughly half of all individuals over the age of 18 use some form of dietary supplementation, and similar figures are noted globally.¹ The use of supplements is more common among male athletes than female athletes, however.

Surveys have shown a variety of reasons for supplement use, including overall health maintenance and deficiency management. Athletes report performance enhancement, muscle recovery and even mood support as benefits of their supplement use. Given the specific concerns and needs of female athletes, including bone and joint health, as well as mental health, scientific research continues to reveal the added benefits of supplementation in a female population.

According to the International Journal of Sport Nutrition and Exercise Metabolism, beta-alanine is an established, evidence-based performance supplement widely used by athletes across the globe.² Beta-alanine increases muscle carnosine, preventing the acid buildup that contributes to soreness and fatigue. Studies have shown that this delay in the onset of muscle fatigue leads to increased endurance, extended training at increased intervals and reduced recovery time.³ Organizations such as the International Society of Sports Nutrition (ISSN) and the International Olympic Committee (IOC) recommend proper supplementation with beta-alanine for the vital role it can play in improving athletes’ performance, including cognitive functioning and muscle and bone support.⁴ And beta-alanine supplementation is recommended for vegan athletes whose diet cannot supply optimal levels.

Effects Of Beta-Alanine Supplementation In Women

Supplementation with beta-alanine has been shown to have similar effects on both men and women, as well as noteworthy effects specific to women of varying ages and athletic abilities. In a research trial conducted specifically within the aging population of elite female cyclists, incremental effects were observed on the performance of masters-level female athletes.⁵ Supplementation of beta-alanine for 28 days increased performance via an extended time to exhaustion and the total work completed with associated lactate clearance during passive rest.

A similar 28-day trial studied the effects of beta-alanine supplementation on isokinetic exercise performance and body composition in female masters athletes.⁶ The study concluded that beta-alanine supplementation increased peak torque and capacity and improved lower-body exercise performance.

An examination was also made of the effects of 28 days of beta-alanine supplementation on the physical working capacity at both the fatigue and ventilatory thresholds, maximal oxygen consumption and time to exhaustion in women.⁷ The study noted improved submaximal cycle ergometry performance and time to exhaustion in young women, thought to have resulted from an increased buffering capacity due to elevated muscle carnosine concentrations.

A fourth beta-alanine study on women was conducted to evaluate the effects of beta-alanine supplementation on markers of oxidative stress.⁸ It was the first study to evaluate the effects of beta-alanine supplementation on in vivo antioxidant effects, and extended its use in both aerobic and anaerobic activities.

Finally, a study was conducted specifically on the effects of beta-alanine on body composition, muscular strength and endurance improvements among recreationally active females participating in progressive resistance training.⁹ The research suggested that over an eight-week period, progressive resistance training four times a week, combined with beta-alanine supplementation, may be effective for improving lower-body muscular endurance.

Functions And Mechanisms Of Beta-Alanine

Beta-alanine is a naturally occurring amino acid that supports the synthesis of muscle carnosine in the body. It combines with the amino acid histidine to form the dipeptide called carnosine. Over time, carnosine acts as a buffer to help delay the onset of lactic acid and muscle fatigue and failure while building endurance and improving recovery.

Carnosine is a dipeptide, or a compound made up of two linked amino acids: beta-alanine and histidine. This compound is in the active tissues of the body, including the heart and the brain. Carnosine is instrumental in the improvement of muscle strength and performance during exercise.

Beta-alanine and carnosine work together during the process of glycolysis, or the breaking down of glucose to generate energy. For sustained or intermittent high-intensity exercise, glucose is the body’s primary energy source. When the intensity of a workout increases, equal amounts of lactate and hydrogen ions become the major end-products of glucose metabolism.

These highly reactive hydrogen ions cause a fall in pH in the muscle, a process also referred to as acidification. Throughout a workout, hydrogen ions can be actively transported from the muscle cells and into the circulatory system. However, at higher exercise intensities, the rate of hydrogen ion production becomes increasingly insufficient. Progressive acidification may then occur, especially in the strength-generating fast-twitch muscle fibers.

As the muscle pH falls, it exacerbates the onset of fatigue. This rise in acidity compromises the proteins responsible for power generation and shortening of the muscle fibers. Essentially, carnosine buffers that pH decline. When histidine attaches to beta-alanine, it takes on an additional hydrogen ion. The histidine half of the carnosine molecule acts as a buffer, while the beta-alanine prevents the histidine from combining with other amino acids to form proteins. As a result, high concentrations of carnosine accumulate in the muscle cells. High concentrations of carnosine act as a buffer to delay or prevent muscle fatigue.

Comprehensive Wellness Support

Beta-alanine, the key building block of carnosine, is well known for its buffering pH capacity; however, supplementation with beta-alanine also offers comprehensive wellness support. Carnosine’s antioxidant and anti-glycation can improve heart function and lung capacity, as well as promote healthy aging.¹⁰ Such benefits are especially evident in the studies conducted on master athletes when different activity levels were measured before and after supplementation.

The strong anti-glycation ability of carnosine specifically protects the brain and supports cognitive function and mental acuity.¹¹  It also decreases everyday occasional anxiety, supports memory, delays mental fatigue, speeds up executive function and increases focus.¹² Such mental support has been shown to be a tremendous asset for a wide variety of individuals from female athletes to aging women. Similarly, since carnosine helps regulate muscle contractions and prevents lipid peroxidation in the body, significant potential benefits are available to heart health.10 The same review indicated supplementation with beta-alanine supports healthy circulation and already-healthy blood pressure levels through vasodilation.

Additional benefits include improved muscle function, systemic protection and bone health.¹³ Promoting muscle quality and optimal function is vital in supporting the musculoskeletal frame, aiding balance, and maintaining strength for both athletic and everyday activity. Beta-alanine supplementation has even been shown to improve physical working capacity in older adults.¹⁴ Through its anti-glycation action, carnosine benefits bone and joint health.¹⁰ Supplementation can thus contribute to overall skeletal integrity by directly protecting bone structure and supporting muscle function. Carnosine also chelates heavy metals, supports blood sugar levels already in the healthy range and supports healthy immune system response.¹⁰ The same review indicated its antioxidant properties protect against free radicals throughout the body.

Finally, carnosine levels naturally decrease with age. Supplementing with beta-alanine (as SR CarnoSyn, from NAI) was shown to increase muscle carnosine content and improve the physical capacity of aging adults.¹²

Supplementing with beta-alanine may offer significant benefits for female athletes, from improving physical performance to gaining comprehensive wellness support.

Mark A. LeDoux is founder, chairman and CEO of Natural Alternatives International Inc. (NAI), an organization established in 1980 with facilities in the U.S. and Switzerland engaged in the research, design and manufacture of nutritional supplement programs and products for multinational clients. He is a proud member and leader of many industry organizations.

References
1 Maughan RJ et al. “IOC consensus statement: dietary supplements and the high-performance athlete.” Br J Sports Med. 2018;52:439-455.

2 Peeling P et al. “Evidence-Based Supplements for the Enhancement of Athletic Performance.” Int J Sport Nutr Exerc Metab. 2018;28(2):178-187.

3 Hoffman JR, Varanoske A, Stout JR. “Effects of β-Alanine Supplementation on Carnosine Elevation and Physiological Performance.” Adv Food Nutr Res. 2018;84:183-206.

4 Trexler ET et al. “International society of sports nutrition position stand: Beta-Alanine.” J Int Soc Sports Nutr. 2015;12:30.

5 Glenn JM et al. “Incremental effects of 28 days of beta-alanine supplementation on high-intensity cycling performance and blood lactate in masters female cyclists.” Amino Acids. 2015;47(12):2593-2600.

6 Glenn JM et al. “Effects of 28-Day Beta-Alanine Supplementation on Isokinetic Exercise Performance and Body Composition in Female Masters Athletes.” J Strength Cond Res. 2016;30(1):200-207.

7 Stout JR et al. “Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women.” Amino Acids. 2007;32(3):381-386.

8 Smith AE et al. “Exercise-induced oxidative stress: the effects of β-alanine supplementation in women.” Amino Acids. 2012;43(1):77-90.

9 Outlaw JJ et al. “Effects of β-Alanine on Body Composition and Performance Measures in Collegiate Women.” J Strength Cond Res. 2016;30(9):2627-2637.

10 Hipkiss AR. “Carnosine and its possible roles in nutrition and health.” Adv Food Nutr Res. 2009;57:87-154.

11 Furst T et al. “β-Alanine supplementation increased physical performance and improved executive function following endurance exercise in middle aged individuals.” J Int Soc Sports Nutr. 2018;15:32.

12 Del Favero S et al. “Beta-alanine (Carnosyn) supplementation in elderly subjects (60-80 years): effects on muscle carnosine content and physical capacity.” Amino Acids. 2012;43(1):49-56.

13 Stout JR et al. “The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55-92 Years): a double-blind randomized study.” J Int Soc Sports Nutr. 2008;5:21.

14 McCormack WP. “Oral nutritional supplement fortified with beta-alanine improves physical working capacity in older adults: a randomized, placebo-controlled study.” Exp Gerontol. 2013;48(9):933-939.

Source: Natural Products Insider

The post Benefits Of Beta-Alanine Supplementation For Female Athletes appeared first on CarnoSyn.

NAI purchased the Carlsbad facility in August 2021 and spent 21 months retrofitting the space with a heavy focus on efficient high-volume powder production and gusseted bag packaging. The facility includes two 400 cubic foot fluidizing paddle blenders, two high-speed rotary packaging lines, gravity flow pallet racking systems and provides 67,453 square feet of conditioned manufacturing and warehouse space for raw material and finished product storage. Reactivating the facility will require employee recruitment of approximately 60 people.

“Restarting our facility is a direct result of our growing capacity needs,” shared Mark LeDoux, Chairman and Chief Executive Officer of NAI. “Powder packaged delivery systems are a growing segment within our industry and this plant can provide an annual capacity of over 26 million pounds of high-quality blended powder products. NAI’s expanding manufacturing capabilities is advantageous for our customers and for our local workforce.”

About NAI:
NAI, headquartered in Carlsbad, California, is a leading formulator, manufacturer and marketer of nutritional supplements and provides strategic partnering services to its customers. NAI’s comprehensive partnership approach offers a wide range of innovative nutritional and food products and services to clients including scientific research, proprietary ingredients, customer-specific nutritional or food product formulation, product testing and evaluation, marketing management and support, packaging and delivery system design, regulatory review, and international product registration assistance. For more information about NAI, please visit www.nai-online.com.

Contact:
Renee Michaelson
Director of Global Marketing
NAI/CarnoSyn^® Brands
(760) 736-7700
info@nai-online.com 

The post Natural Alternatives International Scheduled to Reopen U.S. Manufacturing Facility in California to Support Increased Production Needs appeared first on CarnoSyn.

“This new partnership illustrates our confidence in the Brazilian market and Barentz, who will provide an opportunity for more companies and brands to have access to CarnoSyn^®, the safest and most studied beta-alanine available in the world,” shared Aaron Starr, Vice President, CarnoSyn^® Brands. “We are confident that their experience and expertise will help grow and promote CarnoSyn^® Brands in this region. Barentz has worked tirelessly to establish awareness for sports nutrition brands and life science ingredients in Brazil and South America for decades, with a proven track record of success. We look forward to a mutually beneficial business relationship.”

A leading distributor specializing in the life sciences market, Barentz in South America offers high-tech ingredients in various market sectors including dietary supplements, pharmaceuticals, personal care, foods, beverages, and animal nutrition. CarnoSyn^® beta-alanine represents the latest innovative ingredient added to their specialty ingredient portfolio for distribution.

Moses Benzaquen, President Director of Barentz in Brazil, emphasized CarnoSyn^®‘s exceptional quality, representing the pinnacle of muscle health supplements, “As leaders in the distribution market, we consistently pursue the finest global options, and CarnoSyn^® distinguishes itself with proprietary clinical studies, ensuring both efficacy and quality. With the sports nutrition market booming in Brazil, beta-alanine not only addresses athletes’ needs but also resonates with consumers pursuing healthier lifestyles. We are confident in the success of our partnership with CarnoSyn^® Brands.”

About Barentz
Barentz is a leading global Life Science ingredients distributor. The company sources branded specialty ingredients from leading manufacturers worldwide. Their team of ingredient experts provide value-added technical support which includes pre-mixing, blending, ingredients formulations and ingredient testing from state-of-the-art customized formulation centers and application laboratories in EMEA, Americas, and Asia-Pacific. Established in 1953, Barentz has operations in more than 70 countries with a strong presence in Europe and North America and a rapidly growing network in South America and Asia-Pacific. In 2018, Barentz, a world leader in products for the Life Science market, arrived in Brazil through a joint venture with Tovani Benzaquen. The company serves more than 2,000 customers throughout the entire Brazilian territory and surrounding countries. Tovani Benzaquen officially became Barentz from 2024 onward, expanding its portfolio to over 3,000 molecules while ensuring the quality of local service. With a turnover of € 2.5 billion, Barentz now employs around 2,600 people worldwide and serves over 25,000 customers. For more information, visit: www.barentz.com.

About CarnoSyn^® Brands:
CarnoSyn^® Brands feature two clinically studied, patented ingredients available exclusively from Natural Alternatives International, Inc.: CarnoSyn^® instant release beta-alanine powder and SR CarnoSyn^® sustained release beta-alanine tablets. In 2019, CarnoSyn^® beta-alanine successfully obtained NDI status from the FDA and received Self-Affirmed GRAS (Generally Recognized as Safe) status. SR CarnoSyn^®, an advanced delivery form of CarnoSyn^®, received GRAS affirmation in 2017. The GRAS affirmation allows NAI to broaden their product offerings within the food and beverage industries, including medical and other fortified food products. For more information about CarnoSyn^® in sports nutrition, please visit: www.carnosyn.com. For information on SR CarnoSyn^® in healthy aging and wellness, visit www.srcarnosyn.com.

About NAI:
NAI, headquartered in Carlsbad, California, is a leading formulator, manufacturer and marketer of nutritional supplements and provides strategic partnering services to its customers. NAI’s comprehensive partnership approach offers a wide range of innovative nutritional products and services to clients including scientific research, proprietary ingredients, customer-specific nutritional product formulation, product testing and evaluation, marketing management and support, packaging and delivery system design, regulatory review, and international product registration assistance. For more information about NAI, please visit www.nai-online.com.

Contact:
Renee Michaelson
Director of Global Marketing
NAI/CarnoSyn^® Brands
(760) 736-7700
info@nai-online.com 

The post CarnoSyn^® Brands Partners With Barentz for Exclusive Brazilian Distribution of CarnoSyn^® Beta-Alanine appeared first on CarnoSyn.

Over the course of his 25 plus year career in the domestic and international nutritional supplement industry, Conti has established a proven track record of success in building new business within multiple markets.

“Shane is a skilled relationship builder and comes to NAI with a rich knowledge of our company, having worked here in a Senior Business Development Manager role from 2016 to 2021. We are thrilled to welcome him back,” said Ken Wolf, President of NAI. “His leadership, wealth of experience and network of global contacts will help to accelerate our new business objectives while strengthening existing customer relationships.”

In his role as Vice President of Global Sales, Conti oversees the development and implementation of sales strategies, and leads the NAI sales team and client service departments to meet or exceed sales revenue, sales profitability, and budgetary objectives.

Conti shared, “I’m excited to be back at NAI to lead global sales. I look forward to showcasing NAI’s contract manufacturing capabilities and capacities—especially with the recent addition of the new state-of-the-art powder blending and packaging facility in Carlsbad, California.”

About NAI:
NAI, headquartered in Carlsbad, California, is a leading formulator, manufacturer and marketer of nutritional supplements and provides strategic partnering services to its customers. NAI’s comprehensive partnership approach offers a wide range of innovative nutritional products and services to clients including scientific research, proprietary ingredients, customer-specific nutritional product formulation, product testing and evaluation, marketing management and support, packaging and delivery system design, regulatory review, and international product registration assistance. For more information about NAI, please visit www.nai-online.com.

Contact:
Renee Michaelson
Director of Global Marketing
NAI/CarnoSyn^® Brands
(760) 736-7700
info@nai-online.com 

The post Natural Alternatives International Appoints New VP of Global Sales appeared first on CarnoSyn.

The NutraIngredients-USA Awards honors excellence and innovation in ingredients, finished products, companies, people, and initiatives in the nutrition and dietary supplements industry. The Ingredient of the Year category for Healthy Aging celebrates the best the industry has to offer in tailored solutions to remain physically and mentally healthy as we age. The Ingredient of the Year in the Cognitive Function category recognizes the best ingredients dedicated to supporting cognition, memory, alertness, and other cognitive processes. The 2023 NutraIngredients-USA Awards presentation will be a virtual event taking place on Wednesday, July 12, at 11:00 a.m. CT in Chicago.

“The designation of Award Finalist is an honor and a tribute to the many years of rigorous clinical testing and tremendous financial investment in patenting the sustained release formulation,” said Aaron Starr, Vice President, CarnoSyn^® Brands. “SR CarnoSyn^® beta-alanine is truly a game changer when it comes to healthy aging and cognitive function. Consumers are more focused than ever on improving overall health and seek new solutions to stay healthy and active with vitality. By adding SR CarnoSyn® sustained release tablets to their product portfolio as a turnkey private label or custom formulation, wellness brands can answer consumer demand—with a strong focus on the latest in health science innovation.”

Backed by years of clinical research, SR CarnoSyn® unlocks the many benefits of the antioxidant carnosine to help people get more out of life. As we age, our carnosine levels decrease. SR CarnoSyn® is a patented, sustained release form of beta-alanine that stays in the body longer to enable the synthesis of more carnosine for greater bioavailability within the brain, muscles, and other tissues. SR CarnoSyn® supports the body in five important ways: brain health, heart health, bone health, muscle function, and system immunity—all while limiting the paresthesia normally associated with an efficacious dosage of beta-alanine.

“NAI’s expert team has formulated one of the most science-backed dietary supplements available,” said Dr. Di Tan, Director of Scientific Affairs, CarnoSyn^® Brands. “As pioneers in science, NAI goes beyond just following set rules to test extensive parameters and biomarkers; NAI explores what the world of healthy aging and longevity has yet to uncover.”

About CarnoSyn^® Brands:
CarnoSyn^® Brands feature two clinically studied, patented ingredients available exclusively from Natural Alternatives International, Inc.: CarnoSyn^® instant release beta-alanine powder and SR CarnoSyn^® sustained release beta-alanine tablets. In 2019, CarnoSyn^® beta-alanine successfully obtained NDI status from the FDA and received Self-Affirmed GRAS (Generally Recognized as Safe) status. SR CarnoSyn^®, an advanced delivery form of CarnoSyn^®, received GRAS affirmation in 2017. The GRAS affirmation allows NAI to broaden their product offerings within the food and beverage industries, including medical and other fortified food products. For information on SR CarnoSyn^® in healthy aging and wellness, visit srcarnosyn.com. For more information about CarnoSyn^® in sports nutrition, please visit: www.carnosyn.com.

About NAI:
NAI, headquartered in Carlsbad, California, is a leading formulator, manufacturer and marketer of nutritional supplements and provides strategic partnering services to its customers. NAI’s comprehensive partnership approach offers a wide range of innovative nutritional products and services to clients including scientific research, proprietary ingredients, customer-specific nutritional product formulation, product testing and evaluation, marketing management and support, packaging and delivery system design, regulatory review, and international product registration assistance. For more information about NAI, please visit www.nai-online.com.

Contact:
Renee Michaelson
Director of Global Marketing
NAI/CarnoSyn^® Brands
(760) 736-7700
info@nai-online.com

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The post SR CarnoSyn® Sustained Release Beta-Alanine Selected as Finalist for Ingredient of the Year in Healthy Aging and Cognitive Function by NutraIngredients-USA Awards 2023 appeared first on CarnoSyn.