This is where CarnoSyn^® comes in—offering a holistic solution that not only addresses cognitive well-being but also helps maintain muscle health and physical function. With its carnosine-boosting effects, CarnoSyn^® emerges as a unique supplement to help counterbalance muscle mass loss and performance challenges faced by individuals using GLP-1 receptor agonists.

Challenges with GLP-1 Therapies: Muscle Loss and Nutritional Deficiencies

GLP-1 receptor agonists work by mimicking natural hormones that regulate appetite and insulin response. While these medications are highly effective for weight loss and blood sugar management, they may also pose a risk of reducing muscle mass, particularly if weight loss happens rapidly. Some users report decreased energy levels, endurance, and physical strength, which can impair overall well-being.

Moreover, people on these therapies may develop nutritional deficiencies, as reduced appetite leads to lower intake of key nutrients required for muscle health and cognitive function. Several brands and healthcare providers are now focusing on this issue, recommending that individuals incorporate muscle-supportive supplements into their routines to help mitigate the side effects of GLP-1 therapy.

How CarnoSyn^® Helps Support Muscle and Cognitive Health
CarnoSyn^® addresses the muscle and cognitive challenges associated with GLP-1 receptor agonists through a science-backed, multi-functional approach:

1. Carnosine Boost for Muscle Endurance and Fatigue Reduction
   Carnosine, a dipeptide found in muscles, plays a critical role in reducing muscle fatigue and enhancing endurance. CarnoSyn^® boosts carnosine levels, which helps maintain muscle function and helps reduce the risk of performance decline during GLP-1 therapy. This is especially relevant for individuals engaging in exercise to retain muscle mass and prevent muscle degradation.
2. Support for Cognitive Performance and Mental Clarity
   In addition to muscle health, CarnoSyn^® also helps modulate critical brain biomarkers such as BDNF (brain-derived neurotrophic factor) and GFAP (glial fibrillary acidic protein). These biomarkers are essential for brain function, memory, and mood regulation. GLP-1 users, who sometimes experience fatigue or cognitive fog, may benefit from the CarnoSyn^® formula’s ability to support cognitive resilience and mental clarity.
3. A Holistic Approach: Cognitive and Physical Health Synergy
   Unlike many supplements that focus on only one aspect of well-being, CarnoSyn^® delivers a comprehensive solution by supporting both physical and cognitive performance. For people on GLP-1 therapies, maintaining both brain function and muscle strength may be essential for achieving sustainable, long-term health.

Why CarnoSyn^® is a Valuable Addition for GLP-1 Users

1. Muscle Preservation – CarnoSyn^® helps counteract muscle mass loss with its carnosine-boosting effects, helping users to stay active and maintain physical function.
2. Cognitive Support – By helping to modulate biomarkers like BDNF and GFAP, CarnoSyn^® supports mental clarity and cognitive resilience.
3. Fatigue Reduction – CarnoSyn^® helps reduce muscle fatigue, enabling users to maintain energy levels for daily activities and workouts.

Conclusion: A Comprehensive Addition for GLP-1 Users
As GLP-1 receptor agonists become more widely used, it is essential to address the possible side effects that may accompany their benefits. CarnoSyn^® offers a comprehensive solution, helping individuals maintain muscle strength, cognitive function, and energy levels—three critical elements for long-term well-being.

The post Science Spotlight – Supporting Muscle Health and Cognitive Performance for Individuals on GLP-1 Therapies appeared first on CarnoSyn.

Top Benefits of Beta-Alanine for Women’s Athletic Performance

Increase Time to Exhaustion (TTE)
Beta-alanine’s primary function is to increase carnosine levels in muscles, which buffers acid buildup during high-intensity exercise. For women, this translates to longer runs, more reps in the gym, or extended cycling sessions without burning out. By delaying muscle fatigue, beta-alanine empowers women to break through performance plateaus and set new personal records.

Improve Strength and Power
For women focusing on strength training, beta-alanine helps delay fatigue, enabling more powerful lifts and heavier repetitions in exercises like squats, deadlifts, and bench presses. This support is critical for women aiming to develop lean muscle and increase overall strength.

Sustain Energy Throughout the Day
Beta-alanine is not just for workouts—it also supports energy for busy schedules. Whether running errands, staying active with the family, or enjoying outdoor activities like hiking, beta-alanine helps women maintain strength and endurance for everyday demands.

SR CarnoSyn®: A Revolution in Beta-Alanine for Women

Many women may avoid beta-alanine due to paresthesia, the tingling sensation often associated with the supplement. SR CarnoSyn®, a sustained-release beta-alanine formulation, significantly reduces this discomfort while providing the same powerful benefits for endurance and recovery. This advanced formulation makes beta-alanine more accessible to women, allowing them to optimize their fitness routines without experiencing unwanted side effects.

Benefits of Beta-Alanine for Female Athletes

How Beta-Alanine Supports Muscle Recovery and Endurance for Women

Accelerates Post-Workout Recovery

Recovery is an important component of any fitness routine, and beta-alanine plays a pivotal role
in speeding recovery. By reducing muscle soreness and stiffness, beta-alanine allows women to
bounce back from intense training sessions faster and train more frequently.

Increase Carnosine Levels for Long-Term Muscle Health

Carnosine, the compound formed by beta-alanine, neutralizes acidity in muscles during
exercise. Elevated carnosine levels not only prevent fatigue but also support sustainable muscle
health over time.

Improve Cardiovascular Performance

For women focused on cardio-intensive activities like running, cycling, or rowing, beta-alanine
enhances aerobic capacity. It helps manage lactic acid buildup, allowing for smoother, longer-
duration workouts. This boost in cardiovascular performance is ideal for women striving to
achieve their fitness goals, whether they are training for a marathon or staying active in daily
life.

Supports Healthy Aging

As women age, maintaining muscle and bone health becomes increasingly important. A
sustained-release beta-alanine formula like SR CarnoSyn ® contributes to muscle strength,
skeletal integrity, and protects healthy bone structure, ensuring active aging. This benefit
extends beta-alanine’s appeal beyond athletic performance to overall wellness.

Beta-Alanine Guide

Is Beta-Alanine Safe for Women? Proper Usage and Dosage Explained

Safe and Backed by Science
Extensive studies confirm that beta-alanine is safe for women when taken within recommended dosages. CarnoSyn® Brands provides patented, high-quality forms of beta-alanine, ensuring optimal safety and effectiveness.

Managing Side Effects
Some users may experience paresthesia, a harmless tingling sensation. Spacing beta-alanine dosing throughout the day, or by supplementing with a sustained-release option like SR CarnoSyn® minimizes this effect, making beta-alanine more comfortable to use for women sensitive to this sensation. 

Hormone-Friendly Supplementation
Beta-alanine is non-hormonal, meaning it does not disrupt the body’s natural systems. This makes it an excellent choice for women seeking safe and effective performance enhancements.

Dosage Recommendations
To see results, women should take 3.2 to 6.4 grams of beta-alanine daily, divided into smaller doses to ensure maximum absorption and minimal side effects. Consistency is crucial—regular use over a few weeks leads to significant improvements in endurance and recovery.

For women new to beta-alanine supplementation, starting with a loading phase of 4-6 weeks is recommended. This phase helps saturate muscles with carnosine, significantly enhancing endurance and reducing fatigue during workouts. After the loading phase, transitioning to a maintenance dose ensures ongoing performance improvements, making beta-alanine a long-term ally in achieving fitness and wellness goals.

Beta-Alanine Dosage

Achieve Peak Performance with CarnoSyn®

Beta-alanine offers women a unique opportunity to enhance endurance, improve recovery, and maintain long-term wellness. With trusted formulas from CarnoSyn® Brands, beta-alanine supplementation is safe, effective, and accessible for every woman’s needs.

Contact Us

The post Beta-Alanine for Women: Unlocking Endurance and Recovery Potential appeared first on CarnoSyn.

Study Highlights:

• TriBsyn is an encapsulated low-dose β-alanine complex.
• TriBsyn increased plasma β-alanine 4.5-fold compared to conventional β-alanine.
• TriBsyn achieved high plasma concentrations without the sensation of paresthesia.

TriBsyn is a carnosine booster derived from CarnoSyn^® beta-alanine and formulated using proprietary Hydro Oleo technology. This patent-pending formulation provides higher bioavailability and higher potency, enabling efficacious dosages at lower volumes while effectively eliminating paresthesia. The advanced formulation enables absorption through multiple pathways, including direct cellular uptake and traditional gastrointestinal routes, allowing for superior delivery at both the cellular and systemic levels. Adequate availability of beta-alanine is critical for maintaining muscle and promoting cognitive well-being. Efficacious doses of beta-alanine are often associated with harmless but generally uncomfortable symptoms of paresthesia, discouraging adherence to supplementation.

This study aimed to evaluate the bioavailability, pharmacokinetics, and tolerability of a 400 mg Hydro Oleo encapsulated beta-alanine complex (TriBsyn) specifically designed to reduce paresthesia. A randomized, double-blind, single-dose, three-treatment, three-way crossover oral bioavailability study was conducted in healthy older adults under fasting conditions. The study compared TriBsyn with low (400 mg) and high (1200 mg) doses of conventional beta-alanine. TriBsyn (400 mg) achieved a nearly 4.5-fold and 1.3-fold increase in circulating beta-alanine plasma concentrations compared to 400 mg and 1200 mg of conventional beta-alanine, respectively.

Using metrics such as the Visual Analogue Score (VAS) and Qualitative Light Symptoms Inventory (QLSI), sensory side effects were assessed. No paresthesia or adverse effects were reported in the TriBsyn group, while the conventional beta-alanine groups exhibited increasing paresthesia with dose. TriBsyn (400 mg beta-alanine) recorded a VAS score of 0.62 (indicating almost absent symptoms), whereas conventional β-alanine (400 mg) and conventional β-alanine (1200 mg) scored 2.02 and 4.01 respectively. These results highlight the reduced sensory discomfort in the TriBsyn group, despite its higher bioavailability.

“The TriBsyn clinical trial results clearly showed the elimination of paresthesia and an increased pharmacokinetic efficiency, confirming enhanced delivery and exceptional bioavailability,” said Ken Wolf, President and COO of Natural Alternatives International. “With its advanced Hydro Oleo technology and carnosine-boosting effects, TriBsyn provides scientifically proven claims to improve muscle vitality, muscle working capacity, and cognitive performance. It truly sets a new standard in beta-alanine supplementation and helps fill the gap for healthy aging and wellness solutions—especially for the active aging population, GLP-1 users, and those with plant-based diets.”

About CarnoSyn^® Brands:
CarnoSyn^® Brands features three clinically studied, patented and patent pending ingredients available exclusively from Natural Alternatives International, Inc.: CarnoSyn^® instant release beta-alanine powder, SR CarnoSyn^® sustained release beta-alanine tablets, and TriBsyn powder. In 2019, CarnoSyn^® beta-alanine successfully obtained NDI status from the FDA and received Self-Affirmed GRAS (Generally Recognized as Safe) status. SR CarnoSyn^®, an advanced delivery form of CarnoSyn^®, received GRAS affirmation in 2017. The new “paresthesia-free” TriBsyn powder allows NAI to broaden their product offerings within the dietary supplement category, medical food and other fortified food products. To learn more about CarnoSyn^® and SR CarnoSyn^® in sports nutrition and wellness, visit www.carnosyn.com and www.srcarnosyn.com. For more information about our latest innovation, TriBsyn, visit www.tribsyn.com.

About NAI:
NAI, headquartered in Carlsbad, California, is a leading formulator, manufacturer and marketer of nutritional supplements and provides strategic partnering services to its customers. NAI’s comprehensive partnership approach offers a wide range of innovative nutritional products and services to clients including scientific research, proprietary ingredients, customer-specific nutritional product formulation, product testing and evaluation, marketing management and support, packaging and delivery system design, regulatory review, and international product registration assistance. For more information about NAI, please visit www.nai-online.com.

Contact:
Renee Michaelson
Director of Global Marketing
NAI/CarnoSyn^® Brands
info@nai-online.com 

The post Natural Alternatives International and CarnoSyn® Brands Publish Clinical Research Demonstrating TriBsyn™ Delivering Exceptional Bioavailability, Increased Efficiency and Paresthesia Elimination appeared first on CarnoSyn.

How CarnoSyn^® Beta-Alanine Compares to Energy Drinks for Sustained Energy

Short-Term vs. Long-Term Benefits

Energy drinks are known for their immediate boost, thanks to potentially high doses of caffeine and sugar. However, this short-lived surge often comes with an energy crash later.

In contrast, CarnoSyn^® beta-alanine works by increasing carnosine levels in muscles, enhancing endurance and buffering acid buildup over time. Instead of a quick fix, CarnoSyn^® provides sustained benefits, helping athletes push through workouts without the highs and lows associated with most energy drinks.

Impact on Endurance

Energy drinks primarily stimulate the nervous system, offering no direct benefits to muscle endurance unless they are formulated with CarnoSyn^®, which directly supports muscle performance by delaying fatigue and improving time-to-exhaustion. Studies show that consistent CarnoSyn^® beta-alanine supplementation leads to measurable improvements in endurance, making it ideal for athletes engaging in high-intensity or long-duration activities.

Beta-Alanine Athletes

Health Considerations

Many energy drinks are packed with sugar, artificial ingredients, and excessive stimulants, which can contribute to weight gain, jitters, and other health issues. In contrast, CarnoSyn^® beta-alanine offers a clean, additive-free option for sustained energy and endurance.

CarnoSyn^® Beta-Alanine vs. Caffeine: Which Is Better for Endurance and Focus?

Mechanisms of Action

Caffeine works as a stimulant, enhancing alertness and focus by acting on the central nervous system. CarnoSyn^® beta-alanine operates on a different level, targeting the muscles to increase carnosine and buffer acid buildup during exercise. For activities requiring endurance, CarnoSyn^® provides a direct and lasting benefit to muscle performance that caffeine alone cannot match.

Synergy Between the Two

Many pre-workout supplements, including those listed on the CarnoSyn^® Verified website, combine caffeine and beta-alanine to maximize performance and bioavailability. Caffeine delivers a quick mental boost, while beta-alanine supports long-term physical endurance, making them a powerful pair for enhancing workout results.

Avoiding Overstimulation

High doses of caffeine can cause overstimulation, leading to increased heart rate, anxiety, and energy crashes. This is especially problematic for individuals sensitive to stimulants or for those looking to avoid side effects. CarnoSyn^® beta-alanine offers a stimulant-free alternative, making it a safer and more effective choice for improving endurance, particularly for women and older adults.

Why Choose CarnoSyn^® Over Proprietary Pre-Workout Blends

The Hidden Dangers of Proprietary Blends

Many pre-workout blends feature proprietary formulas that obscure the exact quantities of ingredients. This lack of transparency can lead to underdosed key ingredients, excessive stimulants, or the inclusion of artificial fillers. These hidden elements may diminish the effectiveness of the supplement or cause unwanted side effects. CarnoSyn^® beta-alanine offers a cleaner, more transparent option, providing a single, research-backed ingredient you can trust.

Targeted Benefits Without the Guesswork

Pre-workout blends often include a mix of ingredients, making it difficult to pinpoint what is truly delivering results. CarnoSyn^® beta-alanine, as a standalone ingredient, is proven to elevate carnosine levels in muscles, enhancing endurance, reducing fatigue, and supporting recovery. 

Sustainable Performance Gains

While many pre-workout blends rely on stimulants for a quick energy boost, these effects are often short-lived and accompanied by crashes or jittery side effects. CarnoSyn^® beta-alanine takes a different approach, focusing on long-term performance by building muscle endurance and strength over time. This sustained benefit makes it a smart choice for athletes looking for reliable and lasting improvements along their fitness journey.

Trust CarnoSyn^® for Proven Performance

CarnoSyn^® beta-alanine offers an alternative to most energy drinks, caffeine, and traditional pre-workout blends. While most energy drinks provide short-term boosts and caffeine enhances focus, CarnoSyn^® delivers long-lasting endurance, strength, and recovery. Its clean formulations and sustained-release option, SR CarnoSyn^®, provide consistent support and reduced paresthesia for a more gradual experience.

Contact Us

The post CarnoSyn® Beta-Alanine vs. Popular Alternatives: Energy Drinks, Caffeine, and Pre-Workout Supplements appeared first on CarnoSyn.

When and How to Take Beta-Alanine for Optimal Results

Timing Matters

Unlike many pre-workout supplements, beta-alanine does not offer immediate effects after a single dose. Instead, it is most effective when taken consistently over time to build up carnosine levels in the muscles. To see the best results, aim to take beta-alanine daily—even on rest days. This routine ensures your body maintains a steady level in the bloodstream.

Daily Dosage Recommendations

The recommended daily intake of beta-alanine ranges from 3.2 to 6.4 grams, divided into smaller doses to minimize the risk of paresthesia—a tingling sensation some users experience. Innovations like SR CarnoSyn^®, a sustained-release beta-alanine formulation, have addressed this issue by enhancing beta-alanine delivery and absorption. This advanced formulation significantly reduces the likelihood of paresthesia, allowing for effective dosing with improved comfort and greater flexibility in supplementation.

Proper Dosage of Beta Alanine

Loading Phase for Maximum Benefits

For those new to beta-alanine, a loading phase of 4-6 weeks is recommended to saturate your muscles with carnosine. This phase significantly enhances endurance and helps reduce fatigue during workouts. Once the loading phase is complete, a maintenance dose will ensure continued performance improvements, making beta-alanine a long-term ally in your fitness journey.

Long-Term Health Benefits

While beta-alanine is celebrated for its performance-enhancing properties, its benefits extend far beyond the gym. By boosting carnosine levels, beta-alanine supports:

• Brain Health: Improved cognitive function and mood.
• Muscle Recovery: Reduced soreness and quicker recovery times.
• Healthy Aging: Enhanced muscle and bone health, as well as immune system support.

Beta-Alanine Guide

Combining Beta-Alanine with Other Supplements for Peak Performance

Beta-Alanine and Creatine

Pairing beta-alanine with creatine are the perfect pair for superior performance and can unlock unmatched benefits for athletes focused on both strength and endurance. While beta-alanine helps buffer lactic acid build-up, creatine boosts energy production, allowing you to train harder and recover faster.

Pairing with Caffeine

Beta-alanine and caffeine work well for those who want a stimulant boost. Caffeine enhances focus and energy, while beta-alanine delays muscle fatigue. For those in search of a stim-free experience, using a sustained-release beta-alanine formula like SR CarnoSyn^® ensures steady performance without the jitters.

Synergy with Branched-Chain Amino Acids (BCAAs)

For recovery-focused athletes, beta-alanine complements BCAAs by reducing muscle soreness and supporting faster recovery, so you can get back to training sooner.

Multivitamins and Beta-Alanine for General Health

For a holistic approach to wellness, pair beta-alanine with multivitamins. This combination supports muscle and bone health, brain function, and immunity, making it ideal for both fitness enthusiasts and those prioritizing healthy aging.

Tips for Incorporating Beta-Alanine Into Your Pre-Workout Routine

Start Small

If you are new to beta-alanine, ease into it with smaller doses of around 800 mg per serving, gradually increasing to the full daily dose. This approach minimizes the chances of experiencing paresthesia.

Mix It Into Your Routine

Beta-alanine is versatile and can be seamlessly added to your pre-workout shake or supplement stack. CarnoSyn^® beta-alanine is available in various convenient formats, ensuring easy integration into your daily regimen.

Use Sustained-Release for Convenience

For those who prefer fewer doses throughout the day, SR CarnoSyn^® simplifies supplementation by providing steady benefits while minimizing tingling sensations.

Consistency Is Key

Unlike quick-fix energy boosters, beta-alanine works best when taken daily. Combining regular supplementation with a balanced diet, hydration, and a solid workout plan ensures optimal results.

Maximize Your Fitness Routine with CarnoSyn^®

CarnoSyn^® beta-alanine is your trusted partner for achieving peak performance, enhancing endurance, and supporting long-term health. Whether you are training for your next big event or simply striving for a healthier lifestyle, CarnoSyn^® Brands provides the science-backed results you need to stay ahead.

Don’t settle for less when it comes to your fitness and wellness goals. Start your journey today with the premium benefits of CarnoSyn^® beta-alanine and experience the difference consistent supplementation can make.

Contact Us

The post Maximizing Your Fitness Routine: The Best Way to Use Beta-Alanine appeared first on CarnoSyn.

Under the terms of the agreement, B&D will distribute NAI’s newly introduced carnosine booster, TriBsyn, to the U.S.-based nutritional dietary supplement, functional food, and beverage market segments. Carnosine, which is naturally produced in the body through the synthesizing of beta-alanine and histidine, is a powerful antioxidant that has been shown to provide health benefits for muscle, brain, heart, bone, and overall systemic health. NAI’s new TriBsyn product is a patent-pending ingredient that utilizes proprietary technology to increase beta-alanine bioavailability and absorption, while effectively eliminating the common paresthesia sensation associated with efficacious dosages of beta-alanine. TriBsyn provides the opportunity to reach untapped consumers from older adults to vegetarians, vegans, and others looking to boost their carnosine levels.

“This strategic partnership between NAI and B&D is a testament to our longstanding business relationship,” said Mark LeDoux, CEO and Chairman of the Board at NAI. “B&D’s reputation and commitment to their customers is unwavering. This distribution agreement will help drive the awareness and growth of the TriBsyn innovation launched in August 2024. We are excited to broaden our distribution efforts with B&D and to share our groundbreaking new ingredient with the industry.”

B&D is a leading distributor specializing in the dietary supplement, functional food and beverage, personal care, pet health, and craft brewery industries. TriBsyn represents the latest innovative ingredient added to B&D’s specialty ingredient portfolio for distribution. Their well-stocked warehouse complements just-in-time inventory needs, and a deep understanding of the industry makes B&D a first-class partner.

“B&D is honored to be NAI’s partner to promote TriBsyn,” stated Bill Van Dyke, B&D President. “TriBsyn fits B&Ds’ portfolio and model extremely well by being a clinically supported and unique dietary ingredient. We believe TriBsyn will be an excellent ingredient for anti-aging, cognitive function, and support of physical activity.”

About B&D Nutritional Ingredients, Inc.
Founded in 1993 and based in Carlsbad, California, B&D Nutritional Ingredients, Inc. is a national leader in the sales, distribution, and marketing of high-quality dietary ingredients and flavors to the dietary supplement, functional food and beverage, personal care, pet health, and craft brewery industries. B&D has a portfolio of premium ingredients from leading manufacturers supporting a wide array of health benefits that today’s consumers are looking for. B&D is active in several industry organizations representing the dietary supplement, personal care, and pet health industries. Memberships include, Natural Products Association, Consumer Healthcare Products Association, Association of American Feed Control Officials, National Animal Supplement Council. For more information, visit www.bdnutritional.com.

About CarnoSyn^® Brands:
CarnoSyn^® Brands feature three clinically studied, patented ingredients available exclusively from Natural Alternatives International, Inc.: CarnoSyn^® instant release beta-alanine powder, SR CarnoSyn^® sustained release beta-alanine tablets, and TriBsyn powder. In 2019, CarnoSyn^® beta-alanine successfully obtained NDI status from the FDA and received Self-Affirmed GRAS (Generally Recognized as Safe) status. SR CarnoSyn^®, an advanced delivery form of CarnoSyn^®, received GRAS affirmation in 2017. The new “paresthesia-free” TriBsyn powder allows NAI to broaden their product offerings within the dietary supplement category, including medical and other fortified food products. To learn more about SR CarnoSyn^® in active nutrition and wellness, visit www.srcarnosyn.com. For more information about the latest innovation, TriBsyn, visit www.tribsyn.com.

About NAI:
NAI, headquartered in Carlsbad, California, is a leading formulator, manufacturer and marketer of nutritional supplements and provides strategic partnering services to its customers. NAI’s comprehensive partnership approach offers a wide range of innovative nutritional products and services to clients including scientific research, proprietary ingredients, customer-specific nutritional product formulation, product testing and evaluation, marketing management and support, packaging and delivery system design, regulatory review, and international product registration assistance. For more information about NAI, please visit www.nai-online.com.

Contact:
Renee Michaelson
Director of Global Marketing
NAI/CarnoSyn^® Brands
(760) 736-7700
info@nai-online.com 

The post CarnoSyn® Brands Announces New U.S. Distribution Agreement With B&D Nutritional Ingredients appeared first on CarnoSyn.

The NAI and CarnoSyn^® Brands team will be available at stand #16 to discuss the latest clinical evidence of TriBsyn, a patent-pending ingredient that utilizes proprietary technology to increase beta-alanine bioavailability and absorption, while effectively eliminating the common paresthesia sensation associated with efficacious dosages of beta-alanine. TriBsyn provides new opportunity to reach untapped consumers from older adults to vegans and anyone focused on wellness. Congress attendees are invited to visit the stand to learn more about this new product innovation.

Aaron Starr, Vice President, CarnoSyn^® Brands stated, “We are excited to exhibit TriBsyn at this year’s ESPEN Congress on Clinical Nutrition and Metabolism and to share details behind the clinically proven ingredient. There is an evolving need and growing demand for healthy aging and wellness solutions, and this proprietary carnosine booster is a game changer for dietary supplement categories, as well as for fortified and medical foods, seeking benefit focus on muscle vitality, cognitive performance, and anti-aging support.”

Following ESPEN, the team will attend the 20^th European Geriatric Medicine Society (EuGMS) Congress in Valencia, Spain on September 18-20.

Find out more about TriBsyn by visiting ESPEN stand #16 or www.tribsyn.com.

About CarnoSyn^® Brands:
CarnoSyn^® Brands feature three clinically studied, patented ingredients available exclusively from Natural Alternatives International, Inc.: CarnoSyn^® instant release beta-alanine powder, SR CarnoSyn^® sustained release beta-alanine tablets, and TriBsyn powder. In 2019, CarnoSyn^® beta-alanine successfully obtained NDI status from the FDA and received Self-Affirmed GRAS (Generally Recognized as Safe) status. SR CarnoSyn^®, an advanced delivery form of CarnoSyn^®, received GRAS affirmation in 2017. The new “paresthesia-free” TriBsyn powder allows NAI to broaden their product offerings within the dietary supplement category, including medical and other fortified food products. To learn more about SR CarnoSyn^® in active nutrition and wellness, visit www.srcarnosyn.com. For more information about the latest innovation, TriBsyn, visit www.tribsyn.com.

About NAI:
NAI, headquartered in Carlsbad, California, is a leading formulator, manufacturer and marketer of nutritional supplements and provides strategic partnering services to its customers. NAI’s comprehensive partnership approach offers a wide range of innovative nutritional products and services to clients including scientific research, proprietary ingredients, customer-specific nutritional product formulation, product testing and evaluation, marketing management and support, packaging and delivery system design, regulatory review, and international product registration assistance. For more information about NAI, please visit www.nai-online.com.

Contact:
Renee Michaelson
Director of Global Marketing
NAI/CarnoSyn^® Brands
(760) 736-7700
info@nai-online.com 

The post CarnoSyn® Brands Showcasing TriBsyn™ at the 46th ESPEN Congress On Clinical Nutrition & Metabolism appeared first on CarnoSyn.

The proprietary TriBsyn formulation successfully removes the common paresthesia sensation associated with efficacious dosages of beta-alanine, creating a brand-new opportunity to reach untapped consumers from older adults to vegetarians and vegans.

Increased carnosine levels have been scientifically proven to provide a significant range of support for general wellness, including:

• Bolstering cognitive performance and improving mental fatigue
• Increasing both muscle function and quality in older adults
• Slowing the process of age-related health and mental decline

In clinical trials, results showed the elimination of paresthesia and an increased pharmacokinetic efficiency, confirming TriBsyn’s enhanced delivery and exceptional bioavailability—improving the absorption of beta-alanine by more than four times compared to conventional beta-alanine. The increased efficiency allows for product formulations with significantly less beta-alanine, thereby improving formulation flexibility for various delivery systems.

“After extensive research and trials, we are proud to announce TriBsyn, which contains CarnoSyn^®, the only beta-alanine approved by the FDA under NDI status,” said Aaron Starr, Vice President, CarnoSyn^® Brands. “With the innovation of a paresthesia-free beta-alanine, TriBsyn sets a new standard in beta-alanine supplementation, ensuring that users can experience the full range of health benefits without the paresthesia or ‘tingling’ often experienced as a side effect. We eagerly anticipate the commercial launch of TriBsyn at our first industry event in September, at the 46th ESPEN Congress on Clinical Nutrition & Metabolism in Milan, Italy.”

Ken Wolf, President of NAI shared, “TriBsyn’s launch will bolster our presence in a plethora of dietary supplement categories as well as fortified and medical foods. There is an evolving need and growing demand for healthy aging and wellness solutions—particularly for the aging population and those with plant-based diets. We look forward to sharing this revolutionary new product with our existing customers as well as creating a new customer following.”

To learn more about TriBsyn visit www.tribsyn.com.

About CarnoSyn^® Brands:
CarnoSyn^® Brands feature three clinically studied, patented ingredients available exclusively from Natural Alternatives International, Inc.: CarnoSyn^® instant release beta-alanine powder, SR CarnoSyn^® sustained release beta-alanine tablets, and TriBsyn powder. In 2019, CarnoSyn^® beta-alanine successfully obtained NDI status from the FDA and received Self-Affirmed GRAS (Generally Recognized as Safe) status. SR CarnoSyn^®, an advanced delivery form of CarnoSyn^®, received GRAS affirmation in 2017. The new “paresthesia-free” TriBsyn powder allows NAI to broaden their product offerings within the dietary supplement category, including medical and other fortified food products. To learn more about SR CarnoSyn^® in active nutrition and wellness, visit www.srcarnosyn.com. For more information about the latest innovation, TriBsyn, visit www.tribsyn.com.

About NAI:
NAI, headquartered in Carlsbad, California, is a leading formulator, manufacturer and marketer of nutritional supplements and provides strategic partnering services to its customers. NAI’s comprehensive partnership approach offers a wide range of innovative nutritional products and services to clients including scientific research, proprietary ingredients, customer-specific nutritional product formulation, product testing and evaluation, marketing management and support, packaging and delivery system design, regulatory review, and international product registration assistance. For more information about NAI, please visit www.nai-online.com.

Contact:
Renee Michaelson
Director of Global Marketing
NAI/CarnoSyn^® Brands
(760) 736-7700
info@nai-online.com 

The post CarnoSyn® Brands Unveils TriBsyn™ – “The World’s First Paresthesia-Free Beta-Alanine Powder” appeared first on CarnoSyn.

CarnoSyn^® beta-alanine plays a significant role in enhancing the effectiveness of creatine supplementation, particularly in scenarios where maintaining optimal muscle function and delaying fatigue are crucial. CarnoSyn^® supplementation increases the levels of muscle carnosine, which serves as a buffer against acidification during intense exercise. This buffering capacity helps to slow the decline in intramuscular pH that occurs with sustained muscle contraction. By mitigating the decrease in pH, CarnoSyn^® supplementation supports the function of the creatine kinase-phosphocreatine (CK-PCr) system.

The CK-PCr system relies on an optimal pH environment for its efficiency in regenerating ATP from ADP. When pH levels drop due to acidification during exercise, the efficiency of the CK-PCr system decreases, leading to reduced muscle power output and eventual fatigue. However, CarnoSyn^® beta-alanine supplementation can help maintain a more favorable pH environment, thereby enhancing the ability of the CK-PCr system to regenerate ATP. Therefore, in conjunction with creatine supplementation, CarnoSyn^® plays a complementary role in optimizing muscle energy metabolism. By increasing buffering capacity and delaying the onset of fatigue, CarnoSyn^® supports the function of the CK-PCr system, leading to improved athletic performance during high-intensity and short-duration activities.

Creatine is a naturally occurring compound found in the body, primarily in the muscles, where it plays a crucial role in energy metabolism. Creatine is involved in the rapid production of ATP (adenosine triphosphate), which is the primary energy currency of cells. When muscles contract, they use ATP for energy, and this ATP is rapidly depleted during intense exercise. Creatine kinase (CK) is an enzyme found in muscles and other tissues that catalyzes the transfer of a phosphate group from phosphocreatine (PCr) to ADP (adenosine diphosphate), forming ATP. This reaction is reversible and occurs rapidly, allowing the regeneration of ATP from ADP, which is essential for maintaining energy levels during high-intensity exercise.

The CK-PCr system refers to the coupled reactions involving creatine kinase and phosphocreatine. Phosphocreatine serves as a readily available high-energy phosphate reservoir that can quickly regenerate ATP from ADP, providing a rapid and immediate source of energy during muscle contraction. However, the efficiency of the CK-PCr system can be compromised under certain conditions, such as decreases in pH (acidification) that occur during intense exercise. This decrease in pH can impair the ability of creatine kinase to regenerate ATP from ADP, leading to a
decrease in muscle power output and eventual fatigue. Supplementation with creatine can increase the levels of phosphocreatine in muscles, thereby enhancing the capacity of the CK-PCr system to regenerate ATP during exercise. Supplementation of creatine and CarnoSyn® beta-alanine has been shown to improve strength, power, and muscle endurance, particularly during high-intensity and short-duration activities.

Overall, creatine and the CK-PCr system play crucial roles in muscle energy metabolism, helping to sustain ATP levels and power output during exercise, and supplementation with CarnoSyn^® and creatine can enhance these processes, leading to improved athletic performance. In addition to physical performance benefits, research has shown that CarnoSyn^® and creatine contribute to improved cognitive function. By integrating CarnoSyn^® and creatine into your formulations, you are providing high-quality supplements and a premium consumer experience with the combined benefits of both cognitive and physical performance.

To learn more, visit: https://www.carnosyn.com/carnosyn-creatine/

¹ Hoffman, J et al., 2006. Effect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletes. Int J Sport Nutr and Exercise Metabolism, 16: 430−446.

The post Exploring Creatine Supplementation and the Complementary Role of CarnoSyn® Beta-Alanine in Supporting the Function of the Creatine Kinase-Phosphocreatine System appeared first on CarnoSyn.

While women lead men in dietary supplement purchases, the industry is lacking in female-specific research to support women’s health. The need for this research is not only in regard to female athletes but also to women living active lifestyles. For example, more research is needed that considers the different life stages of women such as perimenopause, menopause, and postmenopause, in both athletes and non-athletes alike. Brands can then use this data to generate new ideas, invest in innovation efforts, and develop new products to support the vast population of women seeking better ways to improve their health and performance through various life stages.

In female study populations ranging from young to old and various levels of physical fitness, the amino acid beta-alanine showed potential benefits.

Insider Takes

• Naturally occurring amino acid beta-alanine supports the synthesis of muscle carnosine in the body.
• Beta-alanine has shown noteworthy effects specific to women of varying ages and athletic abilities.
• Female study populations included aging elite cyclists, young women, masters athletes and actives.

In the U.S., roughly half of all individuals over the age of 18 use some form of dietary supplementation, and similar figures are noted globally.¹ The use of supplements is more common among male athletes than female athletes, however.

Surveys have shown a variety of reasons for supplement use, including overall health maintenance and deficiency management. Athletes report performance enhancement, muscle recovery and even mood support as benefits of their supplement use. Given the specific concerns and needs of female athletes, including bone and joint health, as well as mental health, scientific research continues to reveal the added benefits of supplementation in a female population.

According to the International Journal of Sport Nutrition and Exercise Metabolism, beta-alanine is an established, evidence-based performance supplement widely used by athletes across the globe.² Beta-alanine increases muscle carnosine, preventing the acid buildup that contributes to soreness and fatigue. Studies have shown that this delay in the onset of muscle fatigue leads to increased endurance, extended training at increased intervals and reduced recovery time.³ Organizations such as the International Society of Sports Nutrition (ISSN) and the International Olympic Committee (IOC) recommend proper supplementation with beta-alanine for the vital role it can play in improving athletes’ performance, including cognitive functioning and muscle and bone support.⁴ And beta-alanine supplementation is recommended for vegan athletes whose diet cannot supply optimal levels.

Effects Of Beta-Alanine Supplementation In Women

Supplementation with beta-alanine has been shown to have similar effects on both men and women, as well as noteworthy effects specific to women of varying ages and athletic abilities. In a research trial conducted specifically within the aging population of elite female cyclists, incremental effects were observed on the performance of masters-level female athletes.⁵ Supplementation of beta-alanine for 28 days increased performance via an extended time to exhaustion and the total work completed with associated lactate clearance during passive rest.

A similar 28-day trial studied the effects of beta-alanine supplementation on isokinetic exercise performance and body composition in female masters athletes.⁶ The study concluded that beta-alanine supplementation increased peak torque and capacity and improved lower-body exercise performance.

An examination was also made of the effects of 28 days of beta-alanine supplementation on the physical working capacity at both the fatigue and ventilatory thresholds, maximal oxygen consumption and time to exhaustion in women.⁷ The study noted improved submaximal cycle ergometry performance and time to exhaustion in young women, thought to have resulted from an increased buffering capacity due to elevated muscle carnosine concentrations.

A fourth beta-alanine study on women was conducted to evaluate the effects of beta-alanine supplementation on markers of oxidative stress.⁸ It was the first study to evaluate the effects of beta-alanine supplementation on in vivo antioxidant effects, and extended its use in both aerobic and anaerobic activities.

Finally, a study was conducted specifically on the effects of beta-alanine on body composition, muscular strength and endurance improvements among recreationally active females participating in progressive resistance training.⁹ The research suggested that over an eight-week period, progressive resistance training four times a week, combined with beta-alanine supplementation, may be effective for improving lower-body muscular endurance.

Functions And Mechanisms Of Beta-Alanine

Beta-alanine is a naturally occurring amino acid that supports the synthesis of muscle carnosine in the body. It combines with the amino acid histidine to form the dipeptide called carnosine. Over time, carnosine acts as a buffer to help delay the onset of lactic acid and muscle fatigue and failure while building endurance and improving recovery.

Carnosine is a dipeptide, or a compound made up of two linked amino acids: beta-alanine and histidine. This compound is in the active tissues of the body, including the heart and the brain. Carnosine is instrumental in the improvement of muscle strength and performance during exercise.

Beta-alanine and carnosine work together during the process of glycolysis, or the breaking down of glucose to generate energy. For sustained or intermittent high-intensity exercise, glucose is the body’s primary energy source. When the intensity of a workout increases, equal amounts of lactate and hydrogen ions become the major end-products of glucose metabolism.

These highly reactive hydrogen ions cause a fall in pH in the muscle, a process also referred to as acidification. Throughout a workout, hydrogen ions can be actively transported from the muscle cells and into the circulatory system. However, at higher exercise intensities, the rate of hydrogen ion production becomes increasingly insufficient. Progressive acidification may then occur, especially in the strength-generating fast-twitch muscle fibers.

As the muscle pH falls, it exacerbates the onset of fatigue. This rise in acidity compromises the proteins responsible for power generation and shortening of the muscle fibers. Essentially, carnosine buffers that pH decline. When histidine attaches to beta-alanine, it takes on an additional hydrogen ion. The histidine half of the carnosine molecule acts as a buffer, while the beta-alanine prevents the histidine from combining with other amino acids to form proteins. As a result, high concentrations of carnosine accumulate in the muscle cells. High concentrations of carnosine act as a buffer to delay or prevent muscle fatigue.

Comprehensive Wellness Support

Beta-alanine, the key building block of carnosine, is well known for its buffering pH capacity; however, supplementation with beta-alanine also offers comprehensive wellness support. Carnosine’s antioxidant and anti-glycation can improve heart function and lung capacity, as well as promote healthy aging.¹⁰ Such benefits are especially evident in the studies conducted on master athletes when different activity levels were measured before and after supplementation.

The strong anti-glycation ability of carnosine specifically protects the brain and supports cognitive function and mental acuity.¹¹  It also decreases everyday occasional anxiety, supports memory, delays mental fatigue, speeds up executive function and increases focus.¹² Such mental support has been shown to be a tremendous asset for a wide variety of individuals from female athletes to aging women. Similarly, since carnosine helps regulate muscle contractions and prevents lipid peroxidation in the body, significant potential benefits are available to heart health.10 The same review indicated supplementation with beta-alanine supports healthy circulation and already-healthy blood pressure levels through vasodilation.

Additional benefits include improved muscle function, systemic protection and bone health.¹³ Promoting muscle quality and optimal function is vital in supporting the musculoskeletal frame, aiding balance, and maintaining strength for both athletic and everyday activity. Beta-alanine supplementation has even been shown to improve physical working capacity in older adults.¹⁴ Through its anti-glycation action, carnosine benefits bone and joint health.¹⁰ Supplementation can thus contribute to overall skeletal integrity by directly protecting bone structure and supporting muscle function. Carnosine also chelates heavy metals, supports blood sugar levels already in the healthy range and supports healthy immune system response.¹⁰ The same review indicated its antioxidant properties protect against free radicals throughout the body.

Finally, carnosine levels naturally decrease with age. Supplementing with beta-alanine (as SR CarnoSyn, from NAI) was shown to increase muscle carnosine content and improve the physical capacity of aging adults.¹²

Supplementing with beta-alanine may offer significant benefits for female athletes, from improving physical performance to gaining comprehensive wellness support.

Mark A. LeDoux is founder, chairman and CEO of Natural Alternatives International Inc. (NAI), an organization established in 1980 with facilities in the U.S. and Switzerland engaged in the research, design and manufacture of nutritional supplement programs and products for multinational clients. He is a proud member and leader of many industry organizations.

References
1 Maughan RJ et al. “IOC consensus statement: dietary supplements and the high-performance athlete.” Br J Sports Med. 2018;52:439-455.

2 Peeling P et al. “Evidence-Based Supplements for the Enhancement of Athletic Performance.” Int J Sport Nutr Exerc Metab. 2018;28(2):178-187.

3 Hoffman JR, Varanoske A, Stout JR. “Effects of β-Alanine Supplementation on Carnosine Elevation and Physiological Performance.” Adv Food Nutr Res. 2018;84:183-206.

4 Trexler ET et al. “International society of sports nutrition position stand: Beta-Alanine.” J Int Soc Sports Nutr. 2015;12:30.

5 Glenn JM et al. “Incremental effects of 28 days of beta-alanine supplementation on high-intensity cycling performance and blood lactate in masters female cyclists.” Amino Acids. 2015;47(12):2593-2600.

6 Glenn JM et al. “Effects of 28-Day Beta-Alanine Supplementation on Isokinetic Exercise Performance and Body Composition in Female Masters Athletes.” J Strength Cond Res. 2016;30(1):200-207.

7 Stout JR et al. “Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women.” Amino Acids. 2007;32(3):381-386.

8 Smith AE et al. “Exercise-induced oxidative stress: the effects of β-alanine supplementation in women.” Amino Acids. 2012;43(1):77-90.

9 Outlaw JJ et al. “Effects of β-Alanine on Body Composition and Performance Measures in Collegiate Women.” J Strength Cond Res. 2016;30(9):2627-2637.

10 Hipkiss AR. “Carnosine and its possible roles in nutrition and health.” Adv Food Nutr Res. 2009;57:87-154.

11 Furst T et al. “β-Alanine supplementation increased physical performance and improved executive function following endurance exercise in middle aged individuals.” J Int Soc Sports Nutr. 2018;15:32.

12 Del Favero S et al. “Beta-alanine (Carnosyn) supplementation in elderly subjects (60-80 years): effects on muscle carnosine content and physical capacity.” Amino Acids. 2012;43(1):49-56.

13 Stout JR et al. “The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55-92 Years): a double-blind randomized study.” J Int Soc Sports Nutr. 2008;5:21.

14 McCormack WP. “Oral nutritional supplement fortified with beta-alanine improves physical working capacity in older adults: a randomized, placebo-controlled study.” Exp Gerontol. 2013;48(9):933-939.

Source: Natural Products Insider

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